Imperial college london Study guides, Class notes & Summaries

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on nuclear chromosomes: learn how 2 metres of DNA is somehow packaged into these tiny chromosomes and understand some key features of chromosomes that determine their structure and function. Understand the differences between autosomes, sex chromosomes and mitochondrial chromosomes, and their association with disease. learning objectives: - Recall the changes in numbe...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, Neuroscience (NEU) module. Cerebral ischaemia: an interruption in the blood supply causing disruption of brain function, usually leading to a permanent sensory, motor or cognitive deficit. It is calculated that in England, one in six people will have a stroke in their lifetime. learning outcomes: LO1: Describe the main features of brain blood circulation. LO2: Distinguish between different types of cerebral ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. Lecture 4 on the regulation of blood pressure and flow: - Explain the basic physical principles governing flow and pressure in the circulation. - Describe how vascular resistance is regulated. - Explain how exercise affects the circulation. - Summarise how vascular compliance helps maintain steady blood flow. - Define the terms systolic pressure, diastolic p...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on replication of the genome. Before a cell divides, the entire genome of 3 billion base pairs must first be copied: accurately, quickly and just once per cell cycle. During this replication, chromosomal DNA must be unwound without getting tangled or suffering breakages and, if damage occurs, it must be repaired. Failure to meet any of these requirements may result in damag...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. In this chapter, we are going to take a step into the future to see where current thinking about respiratory and cardiovascular diseases is heading, in particular thinking about where we may be in 10- 15 years’ time. It is a very exciting time for medical research in general, and including respiratory and cardiovascular research, with numerous new technologies ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on genomic DNA. How do we know it is the DNA that genes are made of? In fact, for a long time it was thought that genes must be made of protein. We'll describe how this idea was disproved. Once it was realised that genes were DNA, techniques for analysing DNA burgeoned and gave rise to modern molecular genetics and genomics. We will review the basic principles of some of t...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. "In this last session we will review new and emerging methods, such as single cell sequencing and CRISPR-based genome engineering, and see how they are set to transform areas such a gene therapy, personalised medicine, ageing and the use of non-human organisms. We will also touch on the potential risks and ethical issues raised by these developments." learning objectives: ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...