Highly detailed notes with diagrams and images on gene regulation, targeting 1st or 2nd year biologists and biochemists who wish to have an in-depth knowledge in that area.
This first part of this document explains the importance of gene regulation, the principles and components behind gene regulation. Then moving on to the architecture and differences between prokaryotes and eukaryotes gene regulation and some experimental methods in identifying the cis and trans regulatory elements.
The second part focuses on operons, with detailed explanation of the mechanisms involved in the lac, arabinose and tryptophan operons.
The last part focuses on other regulatory mechanisms, describing chromosomal remodelling, mRNA splicing and miRNA gene regulation.