Molecular Biology of the Cell

BIOL211 - Cell Biology Complete detailed set of notes for a 2nd year Cell Biology module; these notes allowed the achievement of a 1st in the final exam for this module.

BBS2042 Cell Signalling Cases Extensive Cases of BBS2042 - Cell Signalling, contains all thirteen cases with in depth detail and fully written sentences, approximately 88 pages worth of cases/44000 words.

Cancer Biology week 3 - RNA Notes in detail about RNA, from the basics to their role in cancer.

Cancer Biology week 1 & 2- DNA Notes in detail about the DNA structure, function, damage and methods of repair focused on cancer.

DNA Replication and DNA Repair Part 2 Part 2 of DNA Replication and repair, specifically looking at how chromosomes are replicated using accessory proteins and summarising all the proteins forming the machine in DNA replication. Analysing each of these proteins in detail: DNA topoisomerases, telomerase and so on. Briefly looking at the differences between eukaryotes and bacteria in terms of end-replication of chromosomes. Analysing in detail the process of DNA repair, it's importance and the spontaneous changes that can give rise to DNA mutations/damage. Looking at different pathways by which DNA damage can be removed via base excision repair and nucleotide excision repair, non-homologous end-joining and homologous recombination. Overview and brief summary included at the end. These notes are useful in any module covering DNA replication and DNA repair. [Achieved 1st class in 1st year with these notes.]

Priming of Naive T Cells Notes on the activation of T cells by antigen presenting cells (dendritic cells, macrophages and B cells).

Recognition of Antigens by the Adaptive Immune System How the adaptive immune system (B & T Cells) recognise pathogens

LIFE305 Cell Signalling in Health and Disease - Redox signalling Lecture focussing on reactive oxygen species (ROS) production by NAD(P)H oxidase, xanthine oxidase and mitochondria, the role of antioxidants and antioxidative pathways (bacteria: OxyR, mammals: Keap1/Nrf2), pathways of ROS clearance (superoxide dismutase, catalase, glutathione), the effects of ROS (mitochondrial permeability transition/MPT, lipid peroxidation, changes in the ratio of oxidized vs reduced gluthatione, protein carbonylation), techniques to measure ROS and antioxidant activity (N-acetylcysteine, MitoQ10, dihydrorhodamine, mitoSOX) and a little bit of information on reactive nitrogen species (RNS) e.g. nitric oxide.

Apoptosis and Cancer Summary A detailed summary of cancer and apoptosis, exploring these two important areas of human biology. Analysis of cancers are, with examples included and the different types of cancers that exist. Delving into contributing factors and covering the processes of carcinogenesis and apoptosis in detail. Looks at how cancers spread and describing in detail the mechanism of angiogenesis, including activation factors of angiogenesis. Analyse how cancer cells spread by invasion and metastasis. Study in depth oncogenes and tumour suppressor genes and the differences that occur in normal cells and cancerous cells. Investigates cell fusion experiments, the well known p53 tumour suppressor gene and cancer treatment options. These notes are useful in all modules looking at cancer and cellular biology. [Achieved 1st class in 1st year with these notes.]

Effector T Cell Function The different classes of effector T cells including, CD8 cytotoxic T cells, CD4 TH1 Cells, CD4 TH2 Cells, CD4 TH17 Cells, CD4 follicular helper (TFH) cells and CD4 T regulatory (Treg) cells